Paul Durand-Estèbe, Lead Electronic Developer at Metyos, discusses Metyos's groundbreaking wearable glucose monitoring tech, the emergent wearables trend in the medical field, and challenges in scaling and manufacturing wearable medical devices.
Metyos is developing a wearable patch that can provide real-time measurements of biomarkers to help prevent and manage chronic diseases, with a focus on kidney disease monitoring.
Continuous monitoring with the Metyos device offers several advantages over traditional blood sample testing, including continuous data availability for rapidly evolving chronic diseases such as kidney disease and improved patient comfort by avoiding repeated blood draws.
Deep dives
Real-time Monitoring for Chronic Disease Management
Metyos is developing a wearable patch that can provide real-time measurements of biomarkers to help prevent and manage chronic diseases. The device functions similar to a continuous glucose monitor, but it can measure multiple molecules and biomarkers relevant to various diseases. The device uses micronidols on the bottom of the patch to sense interstitial fluid and sends the data via Bluetooth to a smartphone and cloud platform for real-time access by patients and doctors. Continuous monitoring is particularly crucial for chronic diseases like kidney disease, as it allows for early detection of critical points and avoids delays in blood testing and results. The device aims to improve patient comfort while providing accurate and convenient monitoring.
Benefits of Continuous Monitoring
Continuous monitoring with the Metyos device offers several advantages over traditional blood sample testing. First, it provides continuous data availability, which is essential for chronic diseases that can rapidly and dramatically evolve, such as kidney disease. With only blood samples, critical points may be missed or discovered too late. Additionally, continuous monitoring is less intrusive and allows patients to passively detect biomarker levels without the need for repeated blood draws. This improves patient comfort and ensures that no data points are lost. For kidney disease specifically, continuous monitoring can help prevent degradation in patients' quality of life and potentially avoid complications or even death resulting from missed spikes in glucose or other biomarkers.
Expanding the Application of Continuous Monitoring
While the initial focus of Metyos is on kidney disease monitoring, the company has a broad roadmap for expanding the application of their device to other chronic health conditions. By identifying biomarkers relevant to different diseases and finding the proper chemistry to functionalize the electrodes, the device can be adapted for monitoring cardiovascular health, metabolism issues, and more. Metyos sees their device as a platform for chronic disease monitoring, with the ability to measure multiple biomarkers simultaneously. By leveraging continuous monitoring, patients can benefit from early detection and timely intervention, improving overall health outcomes.
Challenges in Scaling and Manufacturing
Scaling up the production of the Metyos device poses challenges both in terms of regulatory requirements and manufacturing processes. The device falls into the medical device category, requiring rigorous clinical trials to prove its effectiveness, safety, and accuracy. Compliance with regulations and obtaining certifications will be crucial in ensuring the device's quality and market approval. On the manufacturing side, Metyos has devised a two-part device with reusable electronics and disposable micro needle sections. This approach allows for easier manufacturing of the micro needle part in parallel with the electronics, as well as sterilization of the micro needle section. Additionally, considerations for wireless charging and ensuring a low-cost yet high-quality production process further add to the manufacturing challenges. Metyos aims to make their device widely available and affordable to maximize its impact on global healthcare.
Today we are joined by Paul Durand-Estèbe, Lead Electronic Developer at Metyos. He and Zach have a fascinating conversation about how Metyos is contributing to the future of wearable medical devices. They focus on Metyos's groundbreaking wearable glucose monitoring tech, the medical field's emergent wearables trend, and much more.
0:00 Intro
1:33 Intro to Paul and Metyos
2:56 A Lesser Invasive Glucose Monitoring Device
5:08 Better Monitoring Faster
8:14 Bad Glucose Monitoring Leads to Disastrous Results
10:52 Potential Chronic Health Monitoring Systems
13:33 Why Start with Kidney Disease?
16:36 From Monitoring to Administering Medication?
18:01 Scaling Challenges (Cutout a minute before this)
22:36 Proving the Effectiveness of the Device
26:54 What Does the Manufacturing Look Like?
31:37 Initial Response to Metyos
35:56 Doctors Receiving Real-time Data
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