This Podcast for the Neurology Journal begins and closes with Dr. John H. Noseworthy, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Erik Ensrud interview Dr. Matthew Menza about his paper on patients with Parkinson disease and depression. In the next segment, Dr. Ryan Overman is reading our e-Pearl of the week about asterixis (part two). The podcast concludes where Dr. Julian Bragg interviews Dr. Steve Buyske for the Lesson of the Week segment. The participants had nothing to disclose except for Dr. Menza. Dr. Menza has received consulting honoraria from NIMH, NINDS, GSK, Kyowa, Lilly Research Laboratories, Pfizer, Sepracor, Takeda, and research support from NINDS, Astra-Zeneca, Bristol-Myers Squibb, Boehringer Ingelheim, Forest Laboratories, GSK, Lilly, Pfizer, Sepracor, Takeda Wyeth and Sanofi-Aventis (where he has also received speaking fees).