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When planning out the architecture of an application in Azure, it is important to consider the cost implications of the different services and resources. While there are tools like the Azure pricing calculator to estimate costs, it is not an exact science and requires careful analysis. Some services, like Document DB, can be surprisingly expensive if not properly managed. One approach to cost optimization is starting with serverless and scaling up to VMs if needed. It's important to understand the scope of responsibility for different services and make sure your application architecture aligns with the most cost-effective options. Additionally, considering the workforce and available skills is crucial. It may be necessary to cross-train developers in operational tasks or have competent personnel to ensure effective cost management. The goal is to find a balance between innovative use of new technologies and leveraging proven, cost-effective solutions.