The Optispan Podcast with Matt Kaeberlein Testosterone, Rapamycin & Diet Myths: A Scientist's AMA | 124
Aug 19, 2025
Dr. Matt Kaeberlein answers burning questions about testosterone therapy and the longevity drug rapamycin. He explains his own injection protocol and offers insights on its use for women. The discussion highlights the pitfalls of excessive supplement regimens and debunks common diet myths, including time-restricted eating. Matt also clarifies the differences between DEXA scans and their importance for body composition. Stick around for entertaining tales from his Ireland trip featuring Guinness and whiskey!
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ITP Water Bottle Story
- Matt received a novelty ITP water bottle and lab coat from the Longevity Biotech Foundation after asking about it.
- The bottle lists ITP compounds like rapamycin and acarbose as a fun memento.
Avoid Unproven Oral Steroids
- Avoid oral synthetic steroids like proviron due to limited long-term safety data and liver metabolism concerns.
- Prefer testosterone therapy if you want a well-studied route with clearer risk profiles.
Testosterone Dosing And Delivery
- Use testosterone cypionate injections if oral forms cause side effects like water retention.
- Matt uses 0.3 mL twice weekly of a 200 mg/mL solution (≈120 mg/week) with anastrozole included.