The Carlat Psychiatry Podcast
Cobenfy: A New Antipsychotic
Oct 7, 2024
Discover the groundbreaking antipsychotic, KarXT, which uniquely doesn't block dopamine, paving new paths in schizophrenia treatment. Dive into its intriguing connections to a 5,000-year-old South Asian herb and the innovative cholinergic effects of xanomaline. The podcast highlights significant clinical trials that reveal KarXT’s efficacy while casting light on its potential advantages over traditional treatments. Addressing both its promise and the uncertainties surrounding its use, it provides a comprehensive look at a fresh hopeful frontier in psychiatry.
12:27
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Quick takeaways
- Cabenphi represents a groundbreaking advancement in antipsychotic treatment by not blocking dopamine, thus potentially reducing common side effects.
- The drug's origins trace back to ancient herbal remedies, demonstrating the importance of revisiting historical treatments in modern psychiatric medicine.
Deep dives
Introduction of Cabenphi as a Novel Antipsychotic
Cabenphi, a newly FDA-approved antipsychotic, marks a significant departure from traditional dopamine-blocking mechanisms. This medication, known as CAR-XT, combines xanomaline, a muscarinic agonist, and trospium, an anticholinergic agent. Xanomaline acts on M1 and M4 receptors, which are linked to cognitive functions and psychotic symptoms, providing a potential alternative treatment for schizophrenia. Unlike conventional antipsychotics, which often cause notable side effects like weight gain and fatigue, Cabenphi demonstrates a reduced likelihood of these adverse effects.
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