Semaglutide, Psoriasis, Magnesium Supplementation | THRR175

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Too Late and Not Enough: School Year Sleep Duration, Timing, and Circadian Misalignment Are Associated with Reduced Insulin Sensitivity in Adolescents with Overweight/Obesity

Show Notes:

Effect of Very-Low-Calorie Ketogenic Diet on Psoriasis Patients: A Nuclear Magnetic Resonance-Based Metabolomic Study

Gluten free

AIP

Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes

Stone Ridge Investor letter 

Questions: 

 

Magnesium Supplementation

Charles writes

Hi Robb and Nikki, I have a question about Magnesium intake. For years I've supplemented 400 mg of Mg nightly based on Rhonda Patrick's recommendation. I always use a highly bioavailable form (e.g. Glycinate or Malate). Recently I've had some discussions with people online who brought to my attention that supplemental Mg *at best* provides like 15% elemental Mg (i.e. a 400 mg supplement gives you 50-60 mg Magnesium). I thought this was fine since I eat a paleo diet rich in fruits and vegetables, which presumably provide a few hundred milligrams of Mg, and I supplement LMNT; but some argue that with our modern soil situation plus anti-nutrients in other foods (not sure if that applies to Paleo people) means that our dietary Mg intake is effectively zero.

My questions:

1) Can you get most of your Mg from food in a reasonably simple Paleo diet?

2) If supplementing, is 400 mg (The Rhonda Patrick recommendation; 50 mg elemental) Mg enough if you do (1)?

3) Can you supplement hundreds of milligrams of elemental Mg without shitting your pants?

Keep up the good work.

Charles

 

Psoriasis

Steve writes: 

Any evidence on any particular dietary solutions to help with psoriasis? I turned 50 and it hit me, mainly my right hand and right foot. Makes lifting difficult. Chalk, Wash, leather up with doc spartan and repeat. I am on a medication, lowest dose. Prefer not to use meds at all, it helps, keeps the tearing pain to an acceptable level to keep moving forward.

 

Semaglutide

Trevor writes: 

What’s the deal with semaglutide? I’ve read that it slows down stomach emptying, but wonder what the health risks might be?

I have a family member who legitimately needs to lose about 100 pounds. They have some orthopedic and neurological issues that make exercise pretty difficult right now. Some version of semaglutide seems pretty appealing right now, if just to get the weight loss ball rolling.

Thanks to you both for your podcast.

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Transcript:

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