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Psychopharmacology and Psychiatry Updates

The Potential of Ashwagandha in Psychiatry

Nov 2, 2024
David Mischoulon, Director of the Depression Clinical and Research Program at Massachusetts General Hospital, dives into the intriguing world of Ashwagandha, a natural remedy with roots in ancient medicine. He discusses its potential in treating anxiety, depression, and OCD, highlighting its promise for patients resistant to conventional treatments. Mischoulon also emphasizes the importance of personalized approaches and careful monitoring when using Ashwagandha, drawing from recent research and clinical insights to inform best practices.
07:48

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Quick takeaways

  • Ashwagandha has shown significant potential in reducing anxiety and stress, demonstrating its usefulness for treatment-resistant psychiatric patients.
  • Clinicians should approach ashwagandha with caution, starting with low doses to monitor effectiveness and side effects due to extract variability.

Deep dives

Potential Benefits of Ashwagandha

Ashwagandha, derived from the Indian winter cherry plant, has shown promise in addressing various psychiatric disorders such as anxiety, depression, OCD, schizophrenia, and substance use disorders. Recent studies, including a meta-analysis of around 1,000 patients, demonstrated that ashwagandha supplementation significantly reduced anxiety and stress levels compared to a placebo. Recommended dosages for stress management range between 300 to 600 milligrams per day, while higher doses, up to 1,200 milligrams, are noted for anxiety treatment. The specific effects of ashwagandha may arise from its ability to decrease apoptosis, reduce oxidative stress, and promote serotonin activity, potentially easing symptoms like insomnia and anxiety.

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