A gene therapy that can reverse deafness in children is discussed, including interviews with a biotech reporter and a little girl who benefited from the treatment. The podcast also explores the effects of swearing on pain tolerance and the impact of deafness treatment on cultural diversity and community thriving.
Read more
AI Summary
Highlights
AI Chapters
Episode notes
auto_awesome
Podcast summary created with Snipd AI
Quick takeaways
Gene therapy shows promise in restoring hearing in children with congenital deafness.
The restoration of hearing through gene therapy raises ethical considerations in the deaf community.
Deep dives
Gene therapy restores hearing in deaf children
Gene therapy has shown promising results in restoring hearing in children with congenital deafness. Several clinical trials have been conducted, primarily in China and the United States, with positive outcomes. The therapy involves adding a gene related to the transmission of signals in the ear cells, allowing them to produce a crucial chemical for hearing. So far, the treatment has been successful in improving the hearing abilities of several children, with results ranging from 60% to 65% of normal speech. While the therapy is not suitable for all forms of deafness, the success of these trials has generated excitement and interest in the field of gene therapy for hearing loss.
Ethical concerns surrounding gene therapy for deafness
The restoration of hearing through gene therapy raises ethical considerations, particularly in the deaf community. While the therapy offers potential benefits for children with congenital deafness, there are concerns about language deprivation and the importance of access to sign language. Some argue that the focus should be on ensuring deaf children have access to language from a young age, rather than viewing gene therapy as a cure. Maintaining the cultural and linguistic diversity of the signing deaf community is crucial, and decisions regarding gene therapy should be fully informed and consider the values and contributions of the community.
Challenges in the widespread application of gene therapy
While gene therapy has shown promise in restoring hearing in select cases of congenital deafness, there are challenges to its widespread application. The success of gene therapies often relies on there being enough patients to make it economically viable. Given the rarity of the specific genetic mutation targeted by this therapy, the number of potential beneficiaries is small. However, the progress in gene therapy for hearing loss does inspire and support further research and development, which may pave the way for more effective treatments for a wider range of deafness cases in the future.
A promising gene therapy can help kids born without the ability to hear. A Deaf bioethicist wants you to consider the implications.
This episode was produced by Victoria Chamberlin, edited by Matt Collette, fact-checked by Haleema Shah and Avishay Artsy, engineered by Patrick Boyd, and hosted by Sean Rameswaram.