NEJM This Week NEJM This Week — April 17, 2025
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Apr 16, 2025 Discover the latest advances in lupus nephritis treatment with obinutuzumab and tecovirimat's role in combating mpox. Dive into a clinical comparison of pulsed field versus cryoballoon ablation for atrial fibrillation. Uncover breakthroughs in hemophilia B therapy and the vital need for proper nutrition in hospitalized patients. Reflect on the implications of the U.S. withdrawal from the WHO and evolving nicotine regulations. Lastly, explore changing healthcare spending trends and the historical impact of physicians during revolutionary times.
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Obinutuzumab Benefits Early Lupus Nephritis
- Obinutuzumab added to standard therapy improved complete renal response in active lupus nephritis patients.
- Early B-cell depletion may prevent disease progression better than reserving treatment for refractory cases.
Tecovirimat Trial Shows No MPOX Benefit
- Tecovirimat showed no efficacy in reducing lesion resolution time in clade-1 MPOX virus infection despite animal model data.
- This trial highlights the importance of rigorous human efficacy trials despite promising non-human results.
Monitoring Enhances Atrial Fibrillation Insights
- Pulsed field ablation (PFA) is as effective as cryoballoon ablation for paroxysmal atrial fibrillation.
- Continuous implantable monitors provide more precise arrhythmia detection and outcome analysis than traditional methods.