The podcast delves into wound healing physiology discussing stages like hemostasis, inflammation, and tissue remodeling. Hilarious banter on energy levels and a childhood story adds a lighthearted touch. Detailed insights on tissue regeneration, different healing intentions, personal injury stories, and factors affecting wound healing are shared.
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Quick takeaways
Primary intention wound healing involves immediate hemostasis with vascular spasm and platelet plugs forming, crucial for clean cuts like scalpel injuries.
Secondary intention wound healing fills voids in deep wounds without primary closure, allowing natural tissue formation with uneven edges.
Tertiary intention healing is suitable for contaminated wounds, requiring cleaning before closure through primary or secondary methods, adapting to specific wound conditions.
Deep dives
Primary Intention Wound Healing
In primary intention wound healing, a clean, neat cut like a scalpel injury results in immediate hemostasis, the stopping of blood flow, through vascular spasm where damaged blood vessels narrow and platelet plugs that form by platelets and exposed collagen binding together. This limits blood loss and initiates clotting cascades to activate proteins involved in clot formation.
Secondary Intention Wound Healing
On the other hand, secondary intention wound healing occurs in cases of uneven, deep wounds with clean edges unable to be brought together neatly. This type of healing involves filling the void created by the wound, allowing tissue to form naturally without primary closure.
Tertiary Intention Wound Healing
Further, tertiary intention healing suits dirty, contaminated, or infected wounds where the area requires time to be cleaned or treated before closing. These wounds can eventually be closed through primary or secondary intention methods once the wound is ready for closure.
Key Points in Blood Clotting Process and Importance of Calcium and Vitamin K
In the podcast, the process of blood clotting is discussed, highlighting how fibrinogen transforms into fibrin via clotting factors produced in the liver. This transformation is crucial for wound healing. The clot, consisting of platelets and fibrin, acts as a natural band-aid over wounds. Calcium and vitamin K are essential for this entire clotting process to occur effectively.
The Phases of Inflammatory Response in Wound Healing
The podcast delves into the inflammatory response during wound healing, featuring stages like hemostasis and inflammation. Chemicals like serotonin and prostaglandins cause blood vessel dilation to facilitate cleanup and healing preparation. Neutrophils and macrophages play vital roles in acute inflammation by ingesting foreign substances and clearing debris. Factors like age, hormonal states, and stress can impact the immune response and overall wound healing process.
In this full length episode, Dr Matt & Dr Mike explain the physiology behind wound healing. Discussing hemostasis, inflammation, proliferation of cells, and tissue remodelling. ENJOY!