Critical Care Time 51. Sepsis
Jun 16, 2025
Dive into the captivating world of sepsis! Explore its historical evolution, from ancient theories to modern breakthroughs. Discover key figures like Semmelweis and Lister, who shaped medical hygiene. The discussion also unpacks steroid use in septic shock and the role of beta blockers in treatment. Gain insights on personalized care approaches and the impact of evolving guidelines. Plus, learn about the Euphrates trial and innovative strategies in sepsis management. Get ready for a thought-provoking journey through critical care!
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The Tragic Story of Semmelweis
- Ignaz Semmelweis discovered that handwashing drastically reduced maternal mortality in the 1840s.
- Despite success, his ideas were rejected, and he died tragically in an asylum beaten by guards.
Emanuel Rivers' Protocol Impact
- Emanuel Rivers' early goal-directed therapy protocol dramatically lowered sepsis mortality in an early trial.
- This approach emphasized early aggressive management, immediately changing practice worldwide.
Sepsis Definitions in 1992
- The 1992 ACCP/SCCM consensus defined SIRS and categorized sepsis severity systematically.
- This laid the foundation for common terminology and practical diagnosis in sepsis care.
