Bloody Minded Episode 50 - Washed Out | Approach to Anaemia
Jun 24, 2025
Uncover the mysteries of anemia in a lively discussion! Explore the importance of blood cell counts, and learn about various types of anemia, including microcytic and macrocytic cases. Delve into thalassemia, iron deficiency, and even lead poisoning with a humorous twist. The hosts simplify complex concepts, making them accessible for medical novices. Plus, discover surprising links between anemia and lifestyle factors like diet and drug use. This enjoyable blend of education and entertainment is sure to make hematology engaging!
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Anemia Definitions Are Arbitrary
- Anemia is defined by WHO as hemoglobin below 130 g/L in men and 120 g/L in women, but these cutoffs are somewhat arbitrary.
- Clinical context and chronicity matter more than strict numbers to decide when anemia is concerning.
MCV Guides Anemia Classification
- Mean corpuscular volume (MCV) is key to classifying anemia as microcytic, normocytic, or macrocytic.
- Red cell size guides the diagnostic pathway and is the first question hematologists ask.
Thalassemia: Inherited Microcytic Anemia
- Thalassemia is a quantitative inherited hemoglobin disorder causing deficient alpha or beta globin chain production.
- It leads to microcytic anemia with high red cell count due to stress erythropoiesis starting from birth.