155: Part 1: Is Wegovy/Ozempic the Miracle Weight Loss Drug It’s Made Out to Be?
Jan 31, 2023
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The podcast dives into the phenomenon of weight loss drugs, particularly Wegovy and Ozempic, asking if they truly live up to the hype. It discusses Novo Nordisk's controversial marketing strategies and ethical dilemmas surrounding fatness. The show also reveals the dual use of Semaglutide and its potential risks for long-term users. Additionally, it examines the shortcomings of clinical trials and the myriad side effects associated with these medications, sparking a broader conversation about sustainable weight loss methods.
Wegovy, primarily made from semaglutide, operates by suppressing appetite but raises concerns about the underlying biases regarding fatness and health.
The marketing of Wegovy by Novo Nordisk reflects ethical issues, as it prioritizes profit over public health and reinforces harmful societal stigmas against fat bodies.
Deep dives
Understanding Wegovy and Its Implications
Wegovy is a weight-loss drug developed by Novo Nordisk, primarily made from semaglutide, a medication originally approved for diabetes management. It operates by suppressing appetite and prolonging satiety, effectively altering the hormonal signals that tell the body when to eat. While it's marketed as a revolutionary solution for obesity, the underlying assumptions driving its approval are contentious, particularly the notion that being fat is inherently unhealthy. This drug's approval reflects broader societal biases against fat bodies, as it targets individuals deemed unhealthy based on their weight rather than their overall health markers.
Novo Nordisk: Marketing and Controversies
Novo Nordisk has a controversial history, transitioning from an insulin manufacturer to a key player in the weight-loss drug market, evidenced by their marketing strategies for Wegovy. The company has faced criticism for price-fixing and misleading advertising regarding the effectiveness and safety of their products. Additionally, they have co-opted language from fat liberation movements to market Wegovy in a way that attempts to frame fatness as a treatable condition rather than a valid embodiment of diversity. This manipulation of narrative places profit over ethical responsibility, mirroring historical patterns of medical exploitation in the pursuit of financial gain.
Efficacy and Safety Concerns
Clinical trials for Wegovy indicate modest weight loss results, averaging around 33 pounds over 68 weeks, but the sustainability of these results is questionable. Studies show that weight regain occurs rapidly after discontinuation of the drug, suggesting that it does not provide a long-term solution to obesity, raising further concerns about its efficacy. Side effects reported include nausea, diarrhea, and potential serious complications like pancreatitis, with about 95% of participants experiencing adverse effects during trials. The drug's long-term safety has not been established, particularly for patients without diabetes, as some research suggests that it may accelerate the onset of diabetes in these individuals.
The Societal Impact of Weight Loss Drugs
The increasing reliance on weight loss drugs like Wegovy raises ethical questions about the societal obsession with thinness and the normalization of pharmaceuticals as solutions to complex health issues. There is concern that these drugs perpetuate the stigma surrounding fat bodies by suggesting that weight loss equates to improved health, which is not necessarily true. Furthermore, the marketing and acceptance of such medications may undermine public health initiatives aimed at promoting body positivity and health at every size. As cultural narratives continue to shape perceptions of body image, the implications of promoting weight loss drugs extend beyond individual health, influencing societal attitudes toward fatness and wellness.
Have you noticed this new craze where influencers and celebs are taking diet drugs, specifically Ozempic/Wegovy? Well if you haven’t then you’re one of the lucky ones! This drug is being touted as “game-changing”, a “miracle” and the “end of ob*sity.” But is it? In this 1st episode of 2, we go into the actual science behind the drug, the clinical trial outcomes and who is the company behind manufacturing the drug…and the hype. TW: mentions of side effects
Episode show notes: http://www.fiercefatty.com/155
A So-Called Game-Changing Weight Loss Drug Is Here—So What Happens Next?: By Ed Cara for Gizmodo: https://gizmodo.com/a-so-called-game-changing-weight-loss-drug-is-here-so-w-1847309279 Wegovy Isn’t A “Game Changer”, But An Update by Mikey Mercedes: https://www.marquiselemercedes.com/writing/wegovy https://untrapped.com.au/weight-loss-drugs-part-2-saxenda-and-wegovy/#more-2729 https://www.wikiwand.com/en/Semaglutide https://www.novomedlink.com/obesity/products/treatments/wegovy/efficacy-safety/clinical-trial-1-results.html https://www.nejm.org/doi/full/10.1056/NEJMoa2032183 https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-treatment-chronic-weight-management-first-2014 https://people.com/health/remi-bader-says-she-gained-double-the-weight-back-after-stopping-weight-loss-drug-ozempic/?utm_source=facebook.com&utm_medium=social&utm_campaign=social-share-article&fbclid=IwAR0biGrvtM0QhVywA_LsYTzJ8Z1Kb2L3OvjIyaVMBP2uxxYGkF_5uUaQQsk&mibextid=Zxz2cZ https://www.drugwatch.com/manufacturers/eli-lilly/ https://www.thecut.com/2022/11/ozempic-side-effects.html https://www.goodrx.com/conditions/weight-loss/wegovy-vs-saxenda https://untrapped.com.au/weight-loss-drugs-part-2 https://canjhealthtechnol.ca/index.php/cjht/article/view/SR0725/953 https://jezebel.com/people-are-buying-raw-chemicals-to-concoct-diy-ozempic-1850012753 https://www.instagram.com/fionawiller/ https://www.instagram.com/p/CnhbcomoM5Z/ What is Wegovy: https://www.goodrx.com/rybelsus/what-is https://www.goodrx.com/wegovy/what-is https://www.goodrx.com/glp-1-agonists https://www.goodrx.com/conditions/diabetes-type-2 https://www.goodrx.com/ozempic/what-is https://www.goodrx.com/rybelsus/what-is https://www.goodrx.com/saxenda/what-is https://www.accessdata.fda.gov/spl/data/dade58f4-0941-498f-87bc-0fa4725ed9a9/dade58f4-0941-498f-87bc-0fa4725ed9a9.xml https://www.goodrx.com/victoza/what-is Overview of the drugs: https://www.wikiwand.com/en/Semaglutide Outcome of the trials: https://docs.google.com/document/d/1I3NMTf7VJoCE_r3Qa_q4gxR7esXGFk1231Qi9snuoFs/edit?usp=sharing Weight Stigma and Marketing: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988332/ https://www.wbur.org/commonhealth/2013/06/21/obesity-ama-fat-acceptance https://blogs.scientificamerican.com/observations/fat-is-not-the-problem-fat-stigma-is/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654677/ This Diabetes Drug Is Being Prescribed Off-Label for Weight Loss. Now There’s a Shortage, Glamour: https://trends.google.com/trends/explore?geo=US&q=ozempic,wegovy,semaglutide,mounjaro https://www.shape.com/lifestyle/mind-and-body/kim-kardashian-full-body-scan https://www.tga.gov.au/alert/joint-statement-prioritisation-semaglutide-ozempic-supply-people-type-2-diabetes-during-shortage https://mutualaiddiabetes.com/ https://www.novopricing.com/ozempic.html https://costplusdrugs.com/medications/categories/diabetes/ https://www.tga.gov.au/alert/joint-statement-prioritisation-semaglutide-ozempic-supply-people-type-2-diabetes-during-shortage https://www.ashp.org/drug-shortages/current-shortages/drug-shortage-detail.aspx?id=813 https://www.drugs.com/drug-shortages/semaglutide-injection-813 https://sports.yahoo.com/ozempic-touted-tiktok-weight-loss-185703390.html Personal stories: https://people.com/health/tiktok-star-remi-bader-treatment-for-binge-eating/ You Might Go Through Hell for Your Post-Ozempic Body, The Cut: https://www.mayoclinic.org/diseases-conditions/type-1-diabetes/expert-answers/lada-diabetes/faq-20057880#:~:text=Latent%20autoimmune%20diabetes%20in%20adults%20(LADA)%20is%20a%20slow%2D,producing%20cells%20in%20the%20pancreas. https://hangrywoman.com/ https://www.youtube.com/watch?v=jn880dmDmPU Did your doc tell you all the warnings including the box warning for thyroid cancer?: https://journalofethics.ama-assn.org/article/informed-consent-what-must-physician-disclose-patient/2012-07 Novo’s Lawsuits and scandals: https://www.drugwatch.com/news/2017/09/13/victoza-maker-paying-58-million-doj-settlement/ https://www.reuters.com/article/us-novo-nordisk-settlement/novo-nordisk-settles-u-s-probe-over-diabetes-drug-for-nearly-58-7-million-idUSKCN1BG315 https://www.justice.gov/opa/press-release/file/994741/download From Fierce Pharma: https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=78734
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