In this episode, Dr. Sara Crager discusses the complexities of selecting vasoactive medications, known as "pressors," for patients in shock. She emphasizes the importance of not just memorizing tables but understanding the underlying principles of why, when, and which pressor to use. Dr. Crager points out the limitations of relying solely on evidence-based medicine for such decisions, highlighting the uniqueness of each patient and the importance of considering provider expertise. She explores various factors, including the need for vasoconstriction, vasodilation, increased inotropy, and concerns about side effects like arrhythmias and pulmonary pressures, to guide the thoughtful selection of the most suitable pressor or combination of pressors to improve tissue perfusion in shock patients.