

Redefining medicine with special guest Dr. Austin Perlmutter
Sep 2, 2025
Dr. Austin Perlmutter, a board-certified internal medicine physician and bestselling author, dives into the intricate link between neuroinflammation and overall health. He discusses how our lifestyle choices—diet, sleep, and stress—impact brain function and well-being. The conversation touches on the role of nutrition in mental health, the benefits of psychedelics for improving cognitive clarity, and how epigenetics can alter our aging process. Listeners gain valuable insights on enhancing resilience and reclaiming mental clarity in a distracted world.
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Family Shaped A Focus On The Brain
- Dr. Austin Perlmutter describes a family history of brain medicine that shaped his interests.
- He shifted from aspiring writer to physician after witnessing his grandfather's Alzheimer's and clinical care challenges.
The Brain Drives Health Through Decisions
- Dr. Perlmutter links decision-making patterns to overall health because the brain drives daily actions that determine health outcomes.
- He frames lifestyle medicine as a way to rewire the brain's architecture to prevent many chronic diseases.
Neuroinflammation Underlies Many Mood Issues
- Neuroinflammation explains many cases of depression beyond classic serotonin models.
- Both COVID infection and lockdown-related lifestyle changes can elevate brain inflammation leading to depression and brain fog.