The Gillett Health Podcast TRT vs Tirzepatide
Aug 22, 2025
Dr. Gillett and James O'Hara delve into a surprising study that suggests tirzepatide might outperform testosterone therapy in boosting testosterone and erectile function. They reveal how metabolic benefits like weight loss drive these improvements. A discussion on lifestyle changes also highlights meaningful testosterone enhancements without drugs. The hosts explore potential issues with testosterone replacement protocols and emphasize the importance of personalized treatment plans. Ultimately, the conversation stresses the synergy between metabolic health and sexual function.
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Tirzepatide Raises Testosterone Indirectly
- Low-dose tirzepatide raised testosterone substantially via metabolic improvements and higher SHBG.
- The drug's effect likely comes from improved insulin, weight loss, and endothelial function rather than direct androgen replacement.
Study's TRT Arm Underperformed
- The testosterone increases with tirzepatide and lifestyle sometimes exceeded those achieved in the study's TRT arm.
- The TRT arm in this trial failed to raise many participants into a normal range, which skews direct comparison.
Trial Titration Likely Biased Results
- The trial appears to have violated its own testosterone titration protocol, limiting TRT dose escalation.
- That methodological issue likely produced a biased result favoring tirzepatide in comparisons.