JAMA Editors' Summary Age-Adjusted D-Dimer Cutoffs, Pediatric Pain Management, Adolescent Smartphone Use, and more
Jan 9, 2026
Discover how age-adjusted D-dimer testing is revolutionizing DVT rule-outs, especially for older adults. Explore the safety of prenatal acid-suppressants on child outcomes. Learn why ibuprofen is now the go-to for managing pediatric limb injuries. Find out about adolescent smartphone use in schools, revealing surprising trends in social media engagement. Plus, hear about new self-collection guidelines for HPV testing and innovative approaches to expanding access to HIV prevention. A blend of timely medical insights and groundbreaking research awaits!
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Age-Adjusted D‑Dimer Improves DVT Efficiency
- Age-adjusted D-dimer (age × 10 µg/L for ≥50) safely ruled out more DVTs without missed events over 3 months.
- This increased negative results particularly in adults ≥75, reducing unnecessary imaging by about 7.4% overall.
No Link Between Prenatal Acid Suppressors And Neuropsychiatric Risk
- Large sibling-matched analysis found prenatal acid-suppressive medication exposure was not linked to child neuropsychiatric disorders after accounting for family factors.
- This suggests family-related confounding explains prior associations in observational studies.
Use Ibuprofen First For Pediatric Limb Pain
- Start pain management for nonoperative pediatric limb injuries with ibuprofen rather than combining with acetaminophen or opioids.
- Avoid routine opioid use because hydromorphone added no benefit and caused more adverse events.