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The podcast discusses the updates on using bisphosphonates to manage bone disease in multiple myeloma. Expert discussions provide insights into the optimal duration and frequency of bisphosphonate usage, highlighting the importance of considering alternatives like denosumab. Research findings reveal the role of metalloprotein MMP13 and its interaction with PD1H on osteoclasts and T cells, potentially impacting bone destruction and immune suppression. These discoveries open new avenues for future research and treatment approaches.