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VJHemOnc Podcast

iwMyeloma 2024 Session I: approaching bone disease, clinical trial updates & the value of MRD as an endpoint in trials

May 10, 2024
Experts Ola Landgren, Suzanne Lentzsch, Thomas Martin, and Suzanne Trudel discuss bone disease treatment in myeloma, updates with isatuximab and belantamab mafodotin, and the value of measurable residual disease (MRD) in clinical trials at the iwMyeloma 2024 session. Topics include bisphosphonates, sequencing strategies, drug approval, and the importance of data-sharing in myeloma research.
27:24

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Quick takeaways

  • Optimal bisphosphonate usage for managing bone disease in myeloma includes considering alternatives like denosumab.
  • Advancements in therapies like esotuximab and belantamab mafodotin show improved outcomes and potential benefits for high-risk patients.

Deep dives

Updates on Bisphosphonates and Bone Disease Management in Multiple Myeloma

The podcast discusses the updates on using bisphosphonates to manage bone disease in multiple myeloma. Expert discussions provide insights into the optimal duration and frequency of bisphosphonate usage, highlighting the importance of considering alternatives like denosumab. Research findings reveal the role of metalloprotein MMP13 and its interaction with PD1H on osteoclasts and T cells, potentially impacting bone destruction and immune suppression. These discoveries open new avenues for future research and treatment approaches.

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