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14min chapter
iwMyeloma 2024 Session I: approaching bone disease, clinical trial updates & the value of MRD as an endpoint in trials
VJHemOnc Podcast
Advancements in Managing Bone Disease in Multiple Myeloma Patients
The chapter explores the latest developments in treating bone disease in multiple myeloma patients, focusing on BIS-Forsonate treatments like zoledronic acid and the alternative NOSOMAP for those with renal failure. Insights on the role of MMP13 metalloproteinase, PD1H interaction, and the reversibility of PD1 alterations post-treatment are discussed. Additionally, it covers the efficacy of esotuxumab, sequencing strategies for different therapies, outcomes of balamaf studies, and the safety profile of combination therapies.
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