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iwMyeloma 2024 Session I: approaching bone disease, clinical trial updates & the value of MRD as an endpoint in trials

VJHemOnc Podcast

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Advancements in Managing Bone Disease in Multiple Myeloma Patients

The chapter explores the latest developments in treating bone disease in multiple myeloma patients, focusing on BIS-Forsonate treatments like zoledronic acid and the alternative NOSOMAP for those with renal failure. Insights on the role of MMP13 metalloproteinase, PD1H interaction, and the reversibility of PD1 alterations post-treatment are discussed. Additionally, it covers the efficacy of esotuxumab, sequencing strategies for different therapies, outcomes of balamaf studies, and the safety profile of combination therapies.

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