PsychRounds: The Psychiatry Podcast The Antipsychotics: Quetiapine (Seroquel)
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Jan 1, 2025 This podcast kicks off the new year by diving into Quetiapine, also known as Seroquel, and its wide-ranging uses beyond psychotic conditions. It discusses the unique mechanisms and side effects, including sedation and metabolic concerns. The KDAD trial is highlighted, comparing its effectiveness for Alzheimer's against other antipsychotics. Clinical applications for geriatric patients and anxiety management are explored, as well as the risks associated with off-label use. Overall, a deep dive into the complexities and nuances of this important medication!
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Quetiapine's Primary Use
- Quetiapine (Seroquel) is the most prescribed antipsychotic in the US.
- It's used less for psychosis and more for mood disorders, delirium, and sleep.
Quetiapine Development History
- Quetiapine was the fourth atypical antipsychotic, developed in the 1980s.
- It aimed to replicate clozapine's benefits without the serious side effects.
Quetiapine's Unique Bipolar Approval
- Quetiapine is uniquely approved for all three phases of bipolar disorder.
- This includes acute mania, bipolar maintenance, and bipolar depression.