The Carlat Psychiatry Podcast Top 10 Findings: Alcohol, ADHD, and Antipsychotics
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Oct 28, 2024 Discover innovative strategies for treating alcohol use disorder with a new drug combination that shows promise for those with co-occurring PTSD. Delve into the complexities of stimulant dosing in ADHD, balancing efficacy and side effects. Learn about a study unveiling that high-dose amphetamines may not help with ADHD symptoms in patients with cannabis use disorder. Plus, examine the surprising results of reducing antipsychotic doses in schizophrenia patients, raising questions about optimal treatment approaches. It's a blend of research and real-world application!
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Antipsychotic Dose Reduction Risks
- Reducing antipsychotic dose in stable schizophrenia does not improve social functioning.
- Dose reduction increased hospitalizations significantly, indicating it is risky after a psychotic episode.
Max Safe Stimulant Doses
- Avoid exceeding 60 mg daily for methylphenidate, and 35 mg daily for Adderall equivalents in adult ADHD.
- Higher doses offer marginal benefit and increase risk of side effects significantly.
Amphetamine Stimulant Risks and Dosing
- Use Vyvanse up to 70 mg due to its steady release reducing peaks causing side effects.
- Limit Adderall to about 30-35 mg daily as higher doses increase risk of mania and psychosis.