The Beautifully Broken Podcast Dr. Joseph Pinzone: Revolutionizing Cancer Treatment Through The Power of Hyperthermia Therapy
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Jul 22, 2024 Join Dr. Joseph Pinzone, Chief Medical Officer of the Hyperthermia Cancer Institute, as he unveils the revolutionary hyperthermia therapy that enhances cancer treatment. He shares how targeted heat boosts the effectiveness of chemotherapy and radiation by increasing blood flow and stimulating the immune response. Dive into three compelling patient success stories and discover the clinical data that highlights improved outcomes for various cancers. Dr. Pinzone also discusses integration into patient care and the future of this groundbreaking therapy.
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How Local Hyperthermia Works
- Hyperthermia uses focused ultrasound to heat solid tumors to ~41–43°C and alters tumor physiology.
- That heat increases blood flow, radiosensitizes tumors, and triggers immune activation via heat-shock proteins.
Heat Makes Chemo and Radiation More Effective
- Heat slows DNA-repair enzymes and increases oxygenation, making radiation and many chemotherapies more effective.
- The combined effect creates higher complete-response rates versus radiation or chemo alone in many studies.
Heating Triggers An Immune Response
- Local fever-level heating releases heat-shock proteins that stimulate antigen presentation and T-cell responses.
- This immune activation can help the body recognize and attack the tumor beyond direct thermal effects.
