This Podcast Will Kill You Ep 176 Strychnine: The WD-40 of Victorian Medicine
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May 20, 2025 Dive into the chilling world of strychnine, once a popular but deadly tonic. Explore its historical medical uses, including a doctor who underestimated its dangers. Uncover the intriguing tale of Jane Stanford and her mysterious poisoning that raised questions of foul play. The hosts also tackle the dark allure of this toxin, discussing its biochemical effects and implications for mental health. Plus, enjoy a quirky musical tribute that connects history and science!
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Dr. Harris's Strychnine Poisoning
- Dr. W.T. Harris experienced strychnine poisoning after ingesting a tonic with an unusually high dose.
- He described severe muscle spasms and loss of control before realizing he was dying.
Mechanism of Strychnine Toxicity
- Strychnine blocks glycine receptors, removing inhibitory control over motor neurons.
- This causes severe muscle spasms but leaves consciousness intact, unlike typical seizures.
Strychnine Treatment Approach
- There is no antidote for strychnine poisoning; treatment focuses on controlling convulsions.
- Medications like benzodiazepines enhance GABA to increase inhibition and reduce spasms.
