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Mechanisms of Line Infection
- Early line infections mostly arise from skin contamination during insertion.
- Late infections happen due to vascular seeding and biofilm formation on the catheter.
Prevent Central Line Infections
- Prevent infections with strict sterility and choosing safer line sites like subclavian.
- Use peripheral pressors when possible to reduce central line use and infection risk.
Blood Culture Strategy for Diagnosis
- Obtain at least two peripheral blood cultures from different sites and one culture from the central line.
- More cultures from different lumens possibly improve detection but use clinical judgment.