In this episode, Dr. Corey Slovis dives into the contentious realm of cardiac arrest management, discussing the use of various drugs including epinephrine, bicarbonate, and calcium. As an expert in emergency medicine, he explores the complexities surrounding these interventions, shedding light on what works and what doesn't in the critical context of cardiac resuscitation. Dr. Slovis emphasizes the importance of securing the ABCs—airway, breathing, and cardiovascular stability—while providing insightful commentary on the recommended dosages and timing of epinephrine administration. He highlights the pivotal role of shockable and non-shockable rhythms in determining the efficacy of epinephrine, drawing from both historical studies and recent double-blind placebo-controlled trials. The host explores the nuanced relationship between epinephrine and neurologic outcomes, addressing the intricate balance between survival and functional quality of life. Dr. Slovis delves into the controversial topics of bicarbonate and calcium use during cardiac arrest, discussing studies that challenge their effectiveness and present potential risks. He advocates for judicious use of these agents and provides practical insights for recognizing scenarios where their administration might be warranted. Throughout the episode, Dr. Slovis engages listeners with his comprehensive review of the literature, critical analysis of evidence, and candid observations on the current state of resuscitative practices. He wraps up the discussion by outlining key takeaways for clinicians, emphasizing the importance of making informed decisions based on the available evidence and patient needs. This episode offers a thought-provoking exploration of the ever-evolving landscape of cardiac arrest management, inviting listeners to rethink established practices and consider the implications for patient outcomes.