A New Understanding of Alzheimer's Disease with Rima Kaddurah-Daouk, MD | MGC Ep. 73

In this episode of The Mind Gut Conversation, I speak with Dr. Rima Kaddurah-Daouk, Professor in the Departments of Medicine and Psychiatry at Duke University Medical School and internationally recognized thought-leader in the pathophysiology of Alzheimer disease.

Dr. Kaddurah currently leads and coordinates an international multi-center research consortium, the Alzheimer’s Disease Metabolomics Consortium or ADMC which consists of more than 120 scientists from over 30 academic institutions.

She has published over 140 peer reviewed scientific publications, leads a large number of active NIH grants and in 2018, she ranked as the highest funded researcher in departments of psychiatry nationally. Dr. Kaddurah has more than 60 patents or patent applications on use of metabolomics for the diagnosis and treatment of brain diseases.

Topics we discuss in this podcast include:

1) What are the major scientific breakthroughs in our understanding of AD that have come from the ongoing research of the NIH AD consortium?

2) The scientific approach on which the AD grant is based on is radically different from the classical reductionistic biomedical research strategy and is based on systems biology and the paradigm of interconnectedness. Based on the lack of progress in effective treatments for AD to date, do you believe this new approach has a better chance of success?

3) Are there any new therapeutic strategies emerging from this new research?