This Podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Interim Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Mark Keegan interview Dr. Murali Ramanathan about his paper on how smoking is associated with multiple sclerosis. In the next segment, Dr. Ryan Overman is reading our e-Pearl of the week about myoclonic status epilepticus. The podcast concludes where Dr. Beau Bruce interviews Dr. Emmanuel Mignot for the Lesson of the Week (Disease) segment about narcolepsy. The participants had nothing to disclose except for Drs. Ramanathan and Mignot.Dr. Ramanathan received research funding from EMD Serono, Pfizer, Novartis, the National Multiple Sclerosis Society, the National Institutes of Health and National Science Foundation. He received compensation for serving as an Editor from the American Association of Pharmaceutical Scientists. These are unrelated to the research presented in this report.Dr. Mignot receives research support from the NIH [#23724 (PI), #MH080957 (PI) and #NS062798 (PI)]. He is also funded by the Howard Hughes Medical Institute, and has received research gifts from Respironics; Cephalon, Inc.; Resmed; Elli Lilly and Company and Jazz Pharmaceuticals.