Breaking Fertility Barriers with Dr. Sherman Silber: Mini-IVF, IVM, and the Future of Reproduction

Dec 3, 2025

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I'm thrilled to sit down with Dr. Sherman Silber, a true pioneer in fertility medicine. Dr. Silber has been at the forefront of groundbreaking advances like mini-IVF, ovarian tissue transplantation, and in vitro maturation (IVM) of eggs. His work has transformed what's possible for patients around the world, and I've admired his contributions since my earliest days in medicine. Together, we dive into the latest innovations and what they mean for anyone thinking about their fertility journey, planning for the future, or exploring new options.

Watch on YouTube: https://youtu.be/TRJ0_35mkBg

Full Show Notes: https://www.draimee.org/breaking-fertility-barriers-with-dr-sherman-silber-mini-ivf-ivm-and-the-future-of-reproduction

In this episode, we cover:

The differences between traditional IVF and in vitro maturation (IVM), and why IVM could be a game-changer
How mini-IVF protocols can improve egg quality and reduce medication side effects
The science and future potential of creating eggs and sperm from skin cells
Ovarian tissue freezing and transplantation as options for fertility preservation and delaying menopause
The unique challenges and solutions for patients with PCOS
The controversies and future of genetic testing and embryo selection (PGT-A and PGTP)
The emotional and practical realities of egg donation, and why it can be a positive choice

Resources:

Dr. Sherman Silber's website
Dr. Silber on Instagram @silberinfertility
Join Dr. Aimee's IVF Class at The Egg Whisperer School
Learn About Dr. Aimee's Fertility Essentials

Do you have questions about IVF?Click here to join Dr. Aimee for The IVF Class. The next live class call is on Monday, December 15, 2025 at 4pm PST, where Dr. Aimee will explain Egg Freezing and there will be time to ask her your questions live on Zoom. Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.