1) Clinical and ethical judgment and 2) Topic of the month: Neuro-infectious diseases. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Dan Larriviere interviews Dr. Ciro Ramos-Estebanez about his paper on clinical and ethical judgment. Dr. Adam Numis is reading our e-Pearl of the week about Brun's nystagmus. In the next part of the podcast Dr. Chenjie Xia interviews Dr. Justin McArthur about the salient and clinically relevant features of HIV and its neurologic complications. The participants had nothing to disclose except Drs. Larriviere, Numis and McArthur.Dr. Larriviere serves as an Associate Editor of Continuum Audio; serves on the editorial advisory board of Neurology Today and receives speaker honoraria from American Association for the Advancement of Science.Dr. Numis serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. McArthur serves on the scientific advisory board of Relevare Pharmaceuticals LTD.; holds stock options in Relevare Pharmaceuticals LTD.; holds a patent for a device for thermal stimulation of small neural fibers with the World Intellectual Property Organization, International Publication Number WO 03/040672 A2, medical device for treatment of ulnar neuropathy. UlnarGuard ™ (JHU Ref: 4545) and immunophilin ligand treatment of antiretroviral toxic neuropathy (Provisional application number 60/466,650).