Extend Podcast with Darshan Shah, MD

64. LP(a): The Massively Important, But Totally Overlooked Biomarker of Heart Attacks, Strokes, and Heart Disease

May 22, 2025
Discover the hidden dangers of LP(a), a biomarker that could put you at higher risk for heart attacks and strokes—often overlooked in standard testing. Learn why even those with healthy lifestyles can have elevated LP(a) levels. This discussion dives into the inflammatory nature of LP(a) compared to LDL, the need for specific lab tests, and why lifestyle changes won't lower it. Get insights on emerging RNA therapies that could reduce LP(a) and actionable steps for managing high levels. It's time to take cardiovascular health seriously!
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INSIGHT

LP(a) Is a Hidden Genetic Risk

  • LP(a) is a genetically determined cholesterol variant that is highly pro-inflammatory and pro-thrombotic.
  • It is not detected in standard cholesterol panels and affects 20% of people worldwide.
ADVICE

Test LP(a) Once in Life

  • Get your LP(a) tested at least once in life since it's genetically stable.
  • Knowing your LP(a) status helps guide risk management for heart disease.
INSIGHT

LP(a) Causes Plaque Despite Lifestyle

  • Elevated LP(a) independently causes atherosclerotic plaques in arteries.
  • Even people with excellent lifestyles can develop artery plaque due to high LP(a).
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