PsychRounds: The Psychiatry Podcast

The Antipsychotics: Aripiprazole (Abilify)

Jan 8, 2025
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INSIGHT

Third-Generation Antipsychotics

  • Aripiprazole, brexpiprazole, and cariprazine are partial dopamine agonists, sometimes grouped with second-generation antipsychotics.
  • They're also called "third-generation" due to their unique mechanism.
INSIGHT

Partial Agonist Mechanism

  • Partial agonists can decrease excessive dopamine action or increase low dopamine action.
  • They act like a "dimming light switch" compared to antagonist "on/off switches".
ANECDOTE

Remembering the "Two Pips and a Rip"

  • Dr. Wang uses "ABC" to remember aripiprazole, brexpiprazole, and cariprazine.
  • Aripiprazole is the second most dispensed antipsychotic in the US, after quetiapine.
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