JAMA Cardiology Author Interviews

Prevalence of HFpEF in Isolated Severe Secondary Tricuspid Regurgitation

Nov 6, 2024
Barry A. Borlaug, a renowned cardiologist at the Mayo Clinic, and Jwan A. Naser, a first-year cardiology fellow, discuss the intriguing relationship between heart failure with preserved ejection fraction (HFpEF) and severe isolated tricuspid regurgitation. They highlight the surprisingly high prevalence of HFpEF in these patients, stressing the need for improved diagnostic methods. The conversation delves into the implications for patient management, advocating for a deeper understanding of underlying conditions like pulmonary hypertension and the role of left atrial function.
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INSIGHT

High HFpEF Prevalence in Isolated TR

  • In a study of severe isolated tricuspid regurgitation (TR), 74% of patients had heart failure with preserved ejection fraction (HFpEF).
  • This finding highlights the importance of looking beyond TR for underlying cardiac issues.
ADVICE

Management Implications of HFpEF in TR

  • Evaluate for underlying conditions like HFpEF or pulmonary hypertension before tricuspid valve intervention.
  • Don't rely solely on echocardiographic diastolic dysfunction or pulmonary hypertension to diagnose HFpEF, as many cases might be missed.
INSIGHT

Ventricular Interdependence in HFpEF

  • Ventricular interdependence, where the right heart impacts left heart filling pressures, plays a role in HFpEF.
  • However, it's not the primary cause of elevated filling pressures in TR patients, which are mainly due to left heart disease.
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