BlueDot Narrated

Scaling US Pathogen Detection

Jan 5, 2026
Explore the innovative approach to pathogen detection in the US. Learn how metagenomic sequencing can identify both known and unknown threats. The discussion covers a $52 million funding proposal aimed at enhancing biosurveillance. Discover how traveler genomic surveillance and wastewater sampling work together for community health. The importance of rapid data sharing and deep sequencing for effective outbreak monitoring is highlighted. The proposed system might significantly improve our ability to detect pandemics before they escalate.
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INSIGHT

$52M Can Fund Early Detection

  • A $52 million annual budget could build a foundational pathogen-agnostic biosurveillance system in the US.
  • The system could detect novel pathogens before 12 in 100,000 Americans are infected and known threats before 1 in 100,000.
INSIGHT

Leverage Existing CDC Programs

  • The model builds on existing CDC programs and centralizes new processing and analysis capabilities.
  • Samples go from TGS and NWSS collection through two centralized labs and shared analysis across agencies and researchers.
ADVICE

Split Funding Strategically

  • Allocate funds across traveller genomic surveillance, advanced molecular detection, and a small wastewater addition.
  • The model apportions $23.7M to TGS, $26.3M to AMD, and $0.8M to NWSS with 35% overhead, totaling $50.8M.
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