

The Science of Longevity with Dr. Joon Yun
Oct 8, 2020
Dr. Joon Yun, a longevity expert and founder of the Palo Alto Longevity Prize, delves into the fascinating mechanics of aging and resilience. He discusses the fractal nature of biology and how our homeostatic capacity can be understood through the 'weeble-wobble' analogy. Dr. Yun emphasizes the importance of occasional indulgence—like eating junk food—and highlights how controlled stress can help rebuild resilience. He also explores the multidimensional aspects of health and how heart rate variability aids in understanding these capacities.
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Homeostatic Capacity As A Weeble Wobble
- Homeostatic capacity is our built-in ability to self-center like a weeble wobble when stressed.
- Dr. Joon Yun says this capacity is robust when young and begins declining around age 40.
Losing Rollercoaster Resilience At 40
- Dr. Joon Yun describes losing tolerance for roller coasters around age 40 as his homeostatic capacity declined.
- He uses personal examples (altitude, diving, temperature) to show narrowing dynamic range with age.
Diseases As Symptoms Of Lost Buffering
- Many age-related diseases may be manifestations of lost homeostatic capacity rather than separate pathologies.
- Dr. Joon Yun suggests reframing hypertension, diabetes, inflammation as failures to return to baseline.