In this video I break down pregnenolone for men on testosterone therapy and share when it helps, when it does nothing, and when it can backfire. We cover the steroidogenesis pathway so you can see where pregnenolone sits as the mother hormone. I explain how TRT suppresses LH and FSH and why that can lower testicular production of upstream steroids even if adrenal output is unchanged. I walk through pregnenolone’s role as a neurosteroid, how it converts to allopregnanolone, and why that often improves sleep quality, stress tolerance, and mood via GABA modulation. I also outline signs of low pregnenolone, summarize what the clinical literature suggests about cognition and anxiety, and give simple dosing guardrails I use personally and with clients. As always none of this is medical advice. Use it to have a smarter conversation with your clinician.

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