talkADHD

ADHD and Medication - explained by an expert. Part 1

19 snips
Oct 3, 2024
Dive into the ADHD medication crisis in the UK and learn about current supply challenges. Discover the significant differences between methylphenidate and dexamphetamine, and how gut health impacts medication effectiveness. The importance of titration and dosage customization is highlighted, alongside conversations about immediate versus extended-release medications. Unpack why some medications feel different and why patient-prescriber communication is crucial for effective treatment. Get ready for a candid exploration of expectations and medication responses.
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INSIGHT

Most People Respond To One Or Both Stimulants

  • Around 70% of people respond to whichever stimulant they start; about 50% respond well to both methylphenidate and dexamphetamine.
  • The remainder may need switching because individual response varies by molecule and person.
ADVICE

Titrate To Match Benefits Versus Side Effects

  • Titrate gradually and judge medication by how unwanted effects compare to benefits at effective doses.
  • Use titration to match dose so wanted effects outweigh unwanted effects.
INSIGHT

Two Drugs, Different Mechanisms

  • Methylphenidate is a dopamine and noradrenaline reuptake inhibitor while dexamphetamine also increases dopamine release.
  • Different mechanisms can produce different subjective effects even if both raise synaptic dopamine.
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