Pioneers of AI Investing in the age of AI, part 2: Jeff Bussgang
May 21, 2025
In this discussion, Jeff Bussgang, a general partner at Flybridge Capital Partners and entrepreneurship professor at Harvard, shares insights from his book, The Experimentation Machine, targeting startups aiming to leverage AI. He discusses practical strategies for building AI-native companies and the critical role of empathy in entrepreneurship. Jeremy Kahn, Fortune's AI editor, highlights geopolitical implications of U.S. investments in AI, particularly in the Gulf region, emphasizing recent deals and their impact on the global AI race.
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AI Native Company Defined
- AI native companies infuse AI into every function and process.
- CEOs ask if AI can replace a hire or improve workflows continuously.
Future Org Charts Include AI
- Org charts now mix humans with hundreds or thousands of AI agents.
- Founders achieve milestones with far fewer employees using AI collaboratively.
Build Defensible AI Products
- To build defensible AI products, focus on proprietary data, user workflows, and human-AI interfaces.
- Simplify and make AI interactions usable to gain competitive advantage.