

Pioneers of AI
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Pioneers of AI is your guide to the latest technological frontier. Each week, host Rana el Kaliouby (AI scientist, investor, author, co-founder of Affectiva) is joined by the leading creators, critics, and thinkers behind mind-blowing technology and asks the important questions about how artificial intelligence is changing the way we live. As we venture together into the unknown, Pioneers is your tool to understanding and anticipating what comes next.
Episodes
Mentioned books

9 snips
Dec 17, 2025 • 21min
‘Like Disneyland when it just opened’: Arm CEO Rene Haas on the AI revolution
In this engaging conversation, Rene Haas, CEO of Arm—whose technology powers billions of devices—shares insights from the forefront of AI infrastructure. He discusses the shift from training to inference and how Arm's low-power CPUs are pivotal for AI on edge devices. Haas boldly predicts that concerns about an AI bubble will fade, emphasizing the transformative potential of AI in fields like life sciences. He also delves into competitive dynamics with NVIDIA and the future of CPU innovations, from memory to robotics.

23 snips
Dec 10, 2025 • 42min
Visualizing the AI boom (or bubble), with Carta’s Peter Walker
Peter Walker, Head of Insights at Carta, dives into the realities of the AI investment landscape. He reveals that 35-40% of capital raised is funneled to AI companies, sparking debates on whether we’re in an AI bubble. Walker highlights the rise of vertical AI and innovative hardware-software combinations while contrasting the hype of mega-rounds against more typical valuations. He also discusses the challenges solo founders face in securing funding, the changing dynamics of startup hiring, and how AI can enhance data visualization.

10 snips
Dec 3, 2025 • 33min
Walmart, AI, and the future of shopping, with Walmart CTO Suresh Kumar
Suresh Kumar, Chief Technology Officer at Walmart, is spearheading a bold AI transformation for the retail giant. He discusses integrating OpenAI to allow customers to shop through ChatGPT and introduces Sparky, Walmart's conversational shopping agent. Kumar delves into using AI for tailored local inventory, enhancing delivery options, and boosting supply chain resilience. He highlights the importance of ethical AI implementation and emphasizes a 'people-led, tech-powered' approach to retail, aiming to improve customer experiences while adapting the workforce.

38 snips
Nov 26, 2025 • 24min
Andrew Ng on winning the AI race, with DJ Patil
In this insightful discussion, Andrew Ng, a pioneering AI educator and co-founder of Coursera and DeepLearning.AI, joins DJ Patil, former U.S. Chief Data Scientist, to explore the future of AI. They delve into the concept of 'agentic' workflows and how they differ from traditional prompting methods. The duo stresses the importance of coding skills alongside AI and discusses the challenges the U.S. faces in maintaining its competitive edge in the global AI landscape. They also examine the role of semiconductors and the need for trust in AI's social acceptance.

40 snips
Nov 19, 2025 • 40min
Mark Cuban’s investment strategy in the world of AI
In this discussion, Mark Cuban, the renowned entrepreneur and Dallas Mavericks owner, dives deep into his AI investment strategies and experiments. He shares insights on using AI avatars for engagement and discusses the potential of AI in preventive medicine. Cuban also explores whether we're in an AI bubble and emphasizes the importance of targeting industries ripe for disruption. He wraps up with advice for young professionals and reflects on the unchanged essence of humanity in the age of AI.

32 snips
Nov 15, 2025 • 43min
Possible: Lisa Su on semiconductors, compute, and big bets
Lisa Su, CEO of AMD, discusses the crucial role of semiconductors in advancing technology and healthcare. She reveals how AMD turned around from near-bankruptcy to a leader in high-performance computing. Lisa highlights AI's potential in accelerating drug discovery and equalizing healthcare access. She also shares insights on navigating geopolitics, the importance of energy efficiency, and fostering a culture of innovation. Su emphasizes the exciting future of AI, envisioning significant improvements in quality of life over the next decade.

22 snips
Nov 12, 2025 • 29min
How AI can unlock life-saving cures, with Siddhartha Mukherjee
Siddhartha Mukherjee, a Pulitzer Prize-winning cancer researcher and co-founder of Manas AI, discusses revolutionary changes in drug discovery. He explains how AI can streamline this lengthy process, making life-saving cures more affordable and accessible. Mukherjee highlights the unique aspects of generative chemistry that differentiate it from traditional AI methods. He also explores the essential role of human oversight in AI-driven discovery, emphasizing that technology should enhance human compassion and creativity.

24 snips
Nov 5, 2025 • 45min
Designing AI for people and the planet, with Aza Raskin
Aza Raskin, co-founder of the Center for Humane Technology and founder of the Earth Species Project, dives deep into the human-centered design of AI. He discusses the unintended consequences of his invention, the infinite scroll, and debates the ethical responsibilities of technologists. Raskin highlights the potential of AI to decode animal communication, revealing fascinating discoveries about animal behavior and culture. He advocates for a collective approach to guide AI development with safety and ethical considerations at its core.

24 snips
Oct 29, 2025 • 37min
Baratunde Thurston wants us to reimagine our relationship with AI
Baratunde Thurston, a comedian and writer known for his podcast Life with Machines, discusses how AI can enrich our human experience rather than diminish it. He emphasizes the need for interdependence between technology and humanity. Thurston shares his journey of integrating an AI co-producer named Blair into his show, the challenges it poses, and the importance of feedback loops. He advocates for democratizing AI access and power, insisting that our emotional and collective agency should guide our relationship with technology.

53 snips
Oct 22, 2025 • 25min
Could this be the future of K-12 education?, with Alpha School’s Joe Liemandt
Joe Liemandt, Principal of Alpha School and seasoned software developer, discusses transforming K-12 education with an AI-driven, mastery-based model. He highlights how students complete core subjects in just two hours, dedicating the rest of the day to social-emotional learning and projects. High school senior Alex Matthew shares insights on creating an AI-powered mental health stuffed animal, Barry, emphasizing the value of feedback and resilience. They explore redefining teachers' roles and the importance of equipping students for an AI-centric future.


