

Pioneers of AI
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Pioneers of AI is your guide to the latest technological frontier. Each week, host Rana el Kaliouby (AI scientist, investor, author, co-founder of Affectiva) is joined by the leading creators, critics, and thinkers behind mind-blowing technology and asks the important questions about how artificial intelligence is changing the way we live. As we venture together into the unknown, Pioneers is your tool to understanding and anticipating what comes next.
Episodes
Mentioned books

35 snips
Nov 26, 2025 • 24min
Andrew Ng on winning the AI race, with DJ Patil
In this insightful discussion, Andrew Ng, a pioneering AI educator and co-founder of Coursera and DeepLearning.AI, joins DJ Patil, former U.S. Chief Data Scientist, to explore the future of AI. They delve into the concept of 'agentic' workflows and how they differ from traditional prompting methods. The duo stresses the importance of coding skills alongside AI and discusses the challenges the U.S. faces in maintaining its competitive edge in the global AI landscape. They also examine the role of semiconductors and the need for trust in AI's social acceptance.

40 snips
Nov 19, 2025 • 40min
Mark Cuban’s investment strategy in the world of AI
In this discussion, Mark Cuban, the renowned entrepreneur and Dallas Mavericks owner, dives deep into his AI investment strategies and experiments. He shares insights on using AI avatars for engagement and discusses the potential of AI in preventive medicine. Cuban also explores whether we're in an AI bubble and emphasizes the importance of targeting industries ripe for disruption. He wraps up with advice for young professionals and reflects on the unchanged essence of humanity in the age of AI.

32 snips
Nov 15, 2025 • 43min
Possible: Lisa Su on semiconductors, compute, and big bets
Lisa Su, CEO of AMD, discusses the crucial role of semiconductors in advancing technology and healthcare. She reveals how AMD turned around from near-bankruptcy to a leader in high-performance computing. Lisa highlights AI's potential in accelerating drug discovery and equalizing healthcare access. She also shares insights on navigating geopolitics, the importance of energy efficiency, and fostering a culture of innovation. Su emphasizes the exciting future of AI, envisioning significant improvements in quality of life over the next decade.

22 snips
Nov 12, 2025 • 29min
How AI can unlock life-saving cures, with Siddhartha Mukherjee
Siddhartha Mukherjee, a Pulitzer Prize-winning cancer researcher and co-founder of Manas AI, discusses revolutionary changes in drug discovery. He explains how AI can streamline this lengthy process, making life-saving cures more affordable and accessible. Mukherjee highlights the unique aspects of generative chemistry that differentiate it from traditional AI methods. He also explores the essential role of human oversight in AI-driven discovery, emphasizing that technology should enhance human compassion and creativity.

24 snips
Nov 5, 2025 • 45min
Designing AI for people and the planet, with Aza Raskin
Aza Raskin, co-founder of the Center for Humane Technology and founder of the Earth Species Project, dives deep into the human-centered design of AI. He discusses the unintended consequences of his invention, the infinite scroll, and debates the ethical responsibilities of technologists. Raskin highlights the potential of AI to decode animal communication, revealing fascinating discoveries about animal behavior and culture. He advocates for a collective approach to guide AI development with safety and ethical considerations at its core.

24 snips
Oct 29, 2025 • 37min
Baratunde Thurston wants us to reimagine our relationship with AI
Baratunde Thurston, a comedian and writer known for his podcast Life with Machines, discusses how AI can enrich our human experience rather than diminish it. He emphasizes the need for interdependence between technology and humanity. Thurston shares his journey of integrating an AI co-producer named Blair into his show, the challenges it poses, and the importance of feedback loops. He advocates for democratizing AI access and power, insisting that our emotional and collective agency should guide our relationship with technology.

53 snips
Oct 22, 2025 • 25min
Could this be the future of K-12 education?, with Alpha School’s Joe Liemandt
Joe Liemandt, Principal of Alpha School and seasoned software developer, discusses transforming K-12 education with an AI-driven, mastery-based model. He highlights how students complete core subjects in just two hours, dedicating the rest of the day to social-emotional learning and projects. High school senior Alex Matthew shares insights on creating an AI-powered mental health stuffed animal, Barry, emphasizing the value of feedback and resilience. They explore redefining teachers' roles and the importance of equipping students for an AI-centric future.

54 snips
Oct 15, 2025 • 21min
Vibe coding and the one-person start-up, with Lovable's Anton Osika
Anton Osika, co-founder and CEO of Lovable, discusses the revolutionary concept of vibe coding, where users can create apps simply by chatting with AI. He reveals how Lovable achieved a rapid $4 billion valuation and highlights its role as a technical co-founder for solo entrepreneurs. Osika explores the impact of vibe coding on traditional software engineering and predicts that most new software will be built using plain-English prompts in the future, empowering global innovation and preserving human creativity.

10 snips
Oct 8, 2025 • 33min
Rapid Response: Hollywood’s hottest AI partner, with Runway’s Cristóbal Valenzuela
Cristóbal Valenzuela, Co-founder and CEO of Runway, shares insights on how AI is revolutionizing creative workflows, particularly in Hollywood. He discusses the balance between leveraging AI tools and maintaining artistic integrity, emphasizing that filmmakers still need skill and intent. Cristóbal contrasts historical media shifts with today's AI advancements and highlights the tool's roles in pre- and post-production. He stresses the responsibility of AI creators to prevent misuse and envisions a future where AI assists in expanding creative possibilities.

22 snips
Oct 1, 2025 • 34min
How Harvey is reinventing legal work with AI
Gabe Pereyra, Co-founder and President of Harvey, is on a mission to revolutionize the legal industry using AI. He discusses how Harvey’s tools assist lawyers with research and drafting, making their work more efficient. Gabe dives into the importance of pairing AI tech with legal expertise and shares insights on addressing challenges like legal data hallucinations. He highlights how AI can reshape career paths in law, enhance enterprise collaboration, and even drive new billing models, all while ensuring client confidentiality remains paramount.


