Precision Oncology in Metastatic Colorectal Cancer: A Real-World Case Study
Sep 24, 2025
Explore the challenges of metastatic colorectal cancer and how precision oncology is reshaping treatment. A case study of a 62-year-old man showcases a personalized care plan developed after standard therapies were exhausted. The discussion dives into genomic profiling, revealing critical mutations that influenced tailored drug combinations. Although the patient faced a tragic outcome, the insights underscore the importance of advanced testing and equitable access to innovative therapies for improved patient care.
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insights INSIGHT
Precision Oncology Matches Treatment To Tumor Genetics
Precision oncology matches therapy to each tumor's unique genetic profile rather than using one-size-fits-all treatments.
This approach helps address variability in tumor behavior after multiple therapy lines and guides tailored interventions.
question_answer ANECDOTE
Real-World Case Of Personalized Care
A 62-year-old man with metastatic colorectal cancer received a personalized plan after five prior treatment lines failed.
His case was reviewed by an international molecular tumor board to design new, individualized strategies.
insights INSIGHT
Genomic Profiling Revealed Actionable Mutations
Comprehensive genetic profiling identified actionable mutations like BRAF, MET, APC, TP53, and NIS in the tumor.
These mutations informed off-label combination therapies aimed at multiple tumor vulnerabilities.
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Colorectal cancer is one of the most common—and deadliest—cancers worldwide. Once it spreads and reaches the metastatic stage, treatment becomes far more difficult. Tumors can also behave very differently from one patient to another, especially after multiple rounds of therapy. Precision oncology is helping to overcome these challenges by enabling clinicians to analyze each tumor’s unique genetic profile and tailor treatment accordingly.
This approach was recently highlighted in a case study published in Volume 16 of Oncotarget. The report detailed how a 62-year-old man with advanced colorectal cancer received a highly personalized treatment plan, developed by an international panel of experts, after completing all standard treatment options.
Full blog - https://www.oncotarget.org/2025/09/24/precision-oncology-in-metastatic-colorectal-cancer-a-real-world-case-study/
Paper DOI - https://doi.org/10.18632/oncotarget.28744
Correspondence to - Shai Magidi - shai.magidi@winconsortium.org
Abstract video - https://www.youtube.com/watch?v=uWDtWNgpK7A
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Keywords - cancer, precision oncology, molecular tumor board, colorectal carcinoma, cancer management
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