JAMA Clinical Reviews

Management of Cirrhosis in 2023

May 9, 2023

Prevalence and causes of cirrhosis in the US, declining prevalence of hepatitis C. Usefulness of history and additional tests in diagnosing cirrhosis. Strategies to improve survival and quality of life for patients with compensated cirrhosis. Management of common symptoms and complications in cirrhosis.

15:06

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Quick takeaways

Non-alcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD) are common causes of cirrhosis in the US.

Regular screening for liver cancer using ultrasound and alpha-fetoprotein is recommended for early detection.

Deep dives

Main Causes and Prevalence of Cirrhosis

Cirrhosis, affecting over 2 million Americans, is commonly caused by non-alcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD). Although hepatitis C used to be a leading cause, increased screening and effective treatment have reduced its prevalence.

Introduction

2min

Diagnosing Cirrhosis: Importance of History, Physical Exam, and Additional Tests

3min

Improving Survival and Quality of Life in Patients with Compensated Cirrhosis

4min

Management of Symptoms in Cirrhosis

3min

Management of Complications in Cirrhosis

4min

Cirrhosis affects approximately 2.2 million adults in the US, and the annual age-adjusted mortality of cirrhosis has increased from 2010 to 2021. JAMA Senior Editor Karen E. Lasser, MD, MPH, and Elliot B. Tapper, MD, from the University of Michigan, discuss the diagnostic workup and evidence-based therapies for cirrhosis. Related Content: