The Dr. Leaf Show What if Your Brain Isn’t Broken—It’s Just NAD Depleted? A Deep Dive into NAD Supplements with Guest Dr. Andrew Salzman of Wonderfeel
Sep 10, 2025
Join Andrew Salzman, a Harvard-trained physician and NAD expert, as he sheds light on the surprising science of brain health. He reveals that cognitive decline is not a given! Discover the critical role of NAD+ in brain function and how its levels decline with age, impacting everything from memory to mental clarity. Andrew shares practical tips to boost brain energy, counteract aging, and enhance longevity. This conversation is a must-listen for anyone looking to keep their mind sharp well into their golden years!
AI Snips
Chapters
Books
Transcript
Episode notes
Aging Is Modifiable, Not Absolute
- Aging is progressive but not fixed; biology allows interventions to slow damage accumulation.
- Understanding the mechanisms of aging lets us extend healthspan, not just lifespan.
NAD: A Ubiquitous Cellular Fuel
- NAD is a small metabolite made in every cell that participates in ~500 reactions across organs.
- Low NAD reduces cellular performance and undermines thinking, movement, immunity, and digestion.
NAD Plummets By Midlife
- NAD levels fall dramatically with age, roughly halving from the 20s to the 50s–60s.
- This large plunge impairs energy-dependent processes across organs as we age.
