a16z Podcast Psychedelics: Striking a Balance Between Benefits and Side Effects
Jan 23, 2021
The podcast delves into the evolving view of psychedelics from recreational highs to serious treatments for mental health issues like depression and addiction. It discusses a promising non-hallucinogenic derivative of Ibogaine, showcasing its potential benefits while addressing safety concerns. Key insights reveal how compounds called psychoplastogens could aid in drug recovery. Moreover, it touches on the regulatory challenges that hinder research, emphasizing the necessity for a more supportive framework to explore these groundbreaking therapies.
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Psychedelic Mechanism
- Psychedelic drugs primarily activate the serotonin 2A receptor.
- Serotonin modulates many brain functions, but psychedelics target this specific receptor.
Therapeutic Effects vs. Hallucinations
- Psychedelic therapeutic effects may come from neuronal growth in the prefrontal cortex, not hallucinations.
- This growth is hypothesized to repair circuits damaged in conditions like depression and PTSD.
Psychedelic Therapy Downsides
- Psychedelic therapy is costly and time-intensive, requiring preparation, supervision, and integration sessions.
- It's also contraindicated for patients with psychotic disorders, limiting its applicability.