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Psychedelics: Striking a Balance Between Benefits and Side Effects

a16z Podcast

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Exploring Ibogaine and Its Derivatives

This chapter examines the psychedelic Ibogaine, highlighting its history and therapeutic potential in treating addiction, while also addressing safety concerns related to cardiovascular risks. It discusses research on TBG, a derivative of ibogaine, showcasing its less toxic properties and fast-acting antidepressant effects that could offer a safer alternative for addiction treatment. Through various experiments, the chapter investigates how TBG reduces alcohol consumption and heroin-seeking behavior in mouse models, hinting at new breakthroughs in addiction therapy.

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