Brain-First or Gut-First? Rethinking Parkinson’s Disease w/ Drs. Ray Dorsey & Michael Okun

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Oct 8, 2025

Drs. Ray Dorsey and Michael Okun, leading neurologists and co-authors of *The Parkinson's Plan*, discuss Parkinson’s as a preventable epidemic linked to toxins in our environment. They explore early warning signs that often go unnoticed, such as loss of smell and constipation. The conversation also covers the increasing incidence of Parkinson’s, emphasizing how pollution and lifestyle choices impact risk. Exercise is highlighted as a crucial therapeutic strategy, and they advocate for practical steps individuals can take to protect their brain health.

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INSIGHT

Parkinson's Is a Growing Whole-Body Problem

Parkinson's is rising rapidly and is not just a brain-only disease.
Ray Dorsey and Michael Okun argue Parkinson's is a whole-body, environment-driven condition.

INSIGHT

Industrial Pollution Shaped Early Cases

Historical air pollution likely contributed to early Parkinson's descriptions in 1817 London.
Ray Dorsey links coal-era pollution and heavy metals to early neurodegenerative signs.

INSIGHT

Nose As Highway For Toxins To The Brain

Tiny airborne particles carry metals into the olfactory nerve and brain.
Ray Dorsey links air pollution and heavy metals to Parkinson's pathology in the nose/olfactory route.

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Today we tackle Parkinson’s as a preventable epidemic—not an inevitable fate. I’m joined on The Dr. Hyman Show by two of the field’s top neurologists, Drs. Ray Dorsey and Michael Okun, co-authors of The Parkinson’s Plan, to unpack why cases are exploding and what we can do about it right now. We look at how toxins drive disease, why Parkinson’s goes far beyond dopamine, and the early signs most people miss—plus what you can do today to protect your brain. And we connect the dots between environmental exposures—whether from food, water, or even recreational spaces—and the growing burden of neurological disease. Watch the full conversation here or listen wherever you get your podcasts. [YOUTUBE THUMBNAIL] We also explore: • How to spot early signs—like loss of smell—long before a diagnosis • Everyday ways to cut toxin exposures in your food, water, and home • Why Parkinson’s is a whole-body disease, and what that means for prevention • The kind of exercise that protects your brain and slows progression • Simple nutrient checks that can support medication and brain health Parkinson’s isn’t inevitable. Protecting brain health starts with small daily choices. These are steps you can take right now for yourself and your loved ones. With awareness and action, you can build resilience today and help shape a healthier future. View Show Notes From This Episode

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