Episode 153 hosts Per Winlof, Chief Design Expert of Galderma based in Uppsala, Sweden. Per leads Galderma’s global R&D and is responsible for all of their filler portfolio from the past, the present and into the future.

Back in 1990 Per was a microbiology student at university in Uppsala. To help supplement his income, he applied for a job at a very small biotech company founded by Dr Bengt Ågerup called ‘Q-Med’. Although fillers were already available (as collagen-based products), Per and his team developed a completely new way of manufacturing fillers made out of a sugar-molecule using bacteria. They launched the world’s first sugar-based dermal filler in 1996.

This new product completely revolutionised the world of facial aesthetics. To this day, approximately 95% of dermal fillers are based on this original technology. Q-Med were acquired by Galderma in 2010 and this podcast celebrates the 25th birthday of the world's first modern filler. 

We explore:

- Per’s background and why he applied for a job at Q-Med?

- Who started Q-Med and why?

- Who developed the original technology of sugar-based fillers and why they were invented in the first place?

- How the idea of facial fillers was conceived?

- The key differences between collagen fillers (available in the early 1990’s) and the newer sugar-based fillers

- How sugar-based fillers are made in the lab?

- The advantages of fillers that don't contain animal products

- Why fillers come in a 1ml syringe?

- What cross-linking is?

- The beginnings of the science of filler rheology: how and why the properties of fillers can differ?

- Filler integration vs tissue integration

- Whether fillers dissolve or not?

- The key safety feature of sugar-based fillers: reversibility and the use of dissolving agents

- Whether Per gave us any clues about what’s coming in the future?

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