Count to 10 - Anaesthetic Primary Podcast EP45 – Glomerular Filtration, Tubular Function & Renal Acid-Base | Anaesthetic Primary Topic | Renal Physiology | CT10
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Nov 18, 2025 Explore the fascinating endocrine roles of the kidneys, including renin production and its impact on blood pressure regulation. Dive into glomerular filtration with insights on its defining characteristics and mechanisms. Understand how tubular function is crucial for sodium, potassium, and glucose handling. Delve into the intricacies of renal acid-base balance, including bicarbonate reabsorption and ammonia excretion. Finally, revisit important learning points through a review of past questions.
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Kidney Is Both Hormone Source And Target
- The kidney both produces hormones and is a target for many systemic hormones, so think in two directions when studying endocrine roles.
- Renin, calcitriol and EPO are the chief hormones produced by the kidney and have distinct triggers and effects.
Renin: Local Sensor To Systemic RAS
- Renin is produced by juxtaglomerular granular cells and is released for low renal perfusion, low tubular NaCl, sympathetic stimulation or prostacyclin.
- Renin cleaves angiotensinogen to start the RAS cascade, and angiotensin II provides negative feedback to suppress renin.
Use GFR = Kf × Net Filtration Pressure
- Memorise the filtration equation: GFR = Kf × net filtration pressure and know what Kf represents.
- Use Starling forces to explain net filtration pressure in exam answers and vivas.