TED Health Interview: What actually causes high cholesterol? | Hei Man Chan
8 snips
Sep 23, 2025 
Dr. Eric Topol, a renowned cardiologist and founder of the Scripps Research Translational Institute, joins to unravel the complexities of cholesterol. They discuss how dietary cholesterol isn't the sole villain, emphasizing the importance of fats and fiber instead. Topol dives into the revolutionary role of AI and genomics in personalized healthcare, advocating for public investment in preventive science. He also highlights the significance of blood biomarkers and the need for future doctors to train in cutting-edge technologies.
AI Snips
Chapters
Books
Transcript
Episode notes
How Lipoproteins Affect Arteries
- LDL is more likely to accumulate on artery walls and trigger inflammation that narrows vessels and causes clots.
- HDL picks up excess LDL and brings it to the liver, helping prevent arterial inflammation.
Genetics Can Drive High LDL
- Some people carry gene variants that impair LDL receptors and raise circulating LDL.
- When lifestyle measures can't control cholesterol, genetic causes may explain persistent elevation.
Fat Type Matters More Than Dietary Cholesterol
- Foods' fat composition affects blood lipids far more than their dietary cholesterol content.
- Saturated and trans fats raise liver production of VLDL/LDL while unsaturated fats are anti-inflammatory.
