Oncotarget
Functional Inhibitor Compounds Inhibit Herpes Simplex Virus Proliferation
Dec 23, 2021
Researchers discuss the challenges in developing specific antiviral drugs due to limited molecular targets in viruses. They explore the use of small compounds to inhibit herpes simplex virus proliferation. Collaborative research focuses on inhibitor compounds for various viruses, including Zika and cytomegalovirus. The podcast outlines the development of wide-range antiviral drugs and drug development plans. Researchers also explore inhibiting virus translation mechanisms for developing effective antiviral drugs.
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Quick takeaways
- Developing specific antiviral drugs is challenging due to limited viral targets and rapid gene evolution.
- Inhibitor compounds targeting host proteins show promise for developing broad-spectrum antiviral drugs.
Deep dives
Interdisciplinary Collaboration in Developing Anti-Drought Compounds
The project involves an interdisciplinary collaboration among three labs to develop anti-drought compounds for plants. It began with the discovery that knocking out a specific gene in plants led to drought resistance. This sparked the interest in creating anti-drought compounds using inhibitor compounds for the Rap1 protein. Through collaboration and testing of over 15 potential binders, around 15 compounds showed promising activity against Rap1.
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