The impact of CYP1A2 gene on caffeine and sleep

The study did not consider the impact of the CYP1A2 gene, which affects caffeine metabolism. Individuals with a certain variant of this gene tend to process caffeine faster, while others process it slower. Slow metabolizers of caffeine may experience a greater impact on sleep after consuming significant amounts of caffeine. The half-life of caffeine is typically around six hours, but slow metabolizers may take significantly longer to eliminate caffeine from their system. Genetic testing can determine an individual's caffeine processing ability, while also highlighting the need for potential adjustment of caffeine intake, especially if sleep disturbances are present.