TED Talks Daily A “living drug” that could change the way we treat cancer | Carl June
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Sep 10, 2019 Carl June, a leading immunologist and the mastermind behind CAR T-cell therapy, shares his revolutionary journey in cancer treatment. He recounts how decades of research led to a breakthrough that empowers the immune system to combat tumors. June highlights the inspiring success story of young Emily Whitehead, who overcame leukemia through this 'living drug'. The discussion dives into the complexities of CAR T-cell therapy, including its costs and the potential to treat various cancers, promising a new era in cancer care.
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Cancer and the Immune System
- Cancer vaccines have been disappointing, working only for virus-caused cancers.
- The immune system struggles with most cancers because they originate from the body's own cells, not external invaders.
Synthetic Immune Systems
- Synthetic immune systems, engineered to target cancer, offer a solution.
- These utilize genetically modified B and T cells, components of the natural immune system.
Early Leukemia Trials
- Carl June's team treated three advanced leukemia patients with CAR T-cell therapy.
- Two patients achieved complete remission, considered cured after eight years, highlighting the potential of this therapy.